Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of...

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Agen%infe)vi:ruoloeziologicoprimarioosolotrigger?RobertoFurlan

Monza,5giugno2017

Infec%onsinMS(andautoimmunity):-  Causal-  Co-factor-  Protec%ve

Causal:EBV

PerronFerranteSotgiuDolei

Sriram

Prototypicalinfec0ousdiseasesandimmunedisorders

BachJF.NEnglJMed2002

Bacteriaandparasiteswithprotec0veeffectsinautoimmunedisease

Helminththerapy

KhanandFallon.IntJParasitol2013

Malariaandautoimmunediseases

•  Thepresenceofaspa0alandtemporalclusterofMSoccurredaJermalariaeradica0on

•  Correla0onbetweenA30-B18-DR3HLAhaplotype,MSandhighmalariaprevalenceareas

•  SomeTNFpolymorphismsintheTNF-promoterregionalreadyassociatedwithbothmalariaandMSareupto100meselevatedamongstSardiniansascomparedtoSiciliansandanyotherpopula0onworldwide

PugliaSetal.Neurology2002Wirzetal.2004Fernandez-Arqueroetal.Neurology1999Knightetal.NatGenet1999McGuireetal.JInfectDis1999

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