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Patrizia Tosi UO Ematologia Rimini - ER Congressi - P...ness. skclctal involvement cspcci'lly of the...

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La prognosi del mieloma multiplo, oggi: Da malattia inguaribile a malattia guaribile Patrizia Tosi UO Ematologia Rimini
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Page 1: Patrizia Tosi UO Ematologia Rimini - ER Congressi - P...ness. skclctal involvement cspcci'lly of the trunk, pathologiml fracture, ancmia or and the pres. ence ot a r inr type of protein

Laprognosidelmielomamultiplo,oggi:

DamalattiainguaribileamalattiaguaribilePatriziaTosi

UOEmatologiaRimini

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Sarah Newbury 1844 Sopravvivenza 4aa dai primi sintomi

Page 3: Patrizia Tosi UO Ematologia Rimini - ER Congressi - P...ness. skclctal involvement cspcci'lly of the trunk, pathologiml fracture, ancmia or and the pres. ence ot a r inr type of protein
Page 4: Patrizia Tosi UO Ematologia Rimini - ER Congressi - P...ness. skclctal involvement cspcci'lly of the trunk, pathologiml fracture, ancmia or and the pres. ence ot a r inr type of protein
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Annals NY Acad Sci 1958

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Annals NY Acad Sci 1958

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Cancerchemotherapyreports1962

Page 8: Patrizia Tosi UO Ematologia Rimini - ER Congressi - P...ness. skclctal involvement cspcci'lly of the trunk, pathologiml fracture, ancmia or and the pres. ence ot a r inr type of protein
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Che cosa è cambiato?

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Lacurvadose-rispostadelMelphalanSRE

Selby et al, BR J Haematol 1987 Attal et al NEJM 1996

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We are indebted to Beth Wolmer for her persistence in recommending the clinical evaluation of thalidomide in the treatment of multiple myeloma……………… This article is dedicated to the memory of Ira Wolmer, M.D

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L

Haematologica 2018

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Ravi et al, Blood cancer journal 2018

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Ravi et al, Blood cancer journal 2018

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“pathwaytocure”Eradicazionedelclone

Metodichepervalutarel’efficaciadeltrattamento(MRD)

Trattamentoprecoce

Nuovicriteridiiniziotrattamento

StudisulMMsmouldering

Identificazionedeipazientiadaltorischio

Trattamentiadhoc(potenziamentodell’immunoterapia?)

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