IL MANGOSTANO
La Medicina tradizionale asiatica usa da secoli questo delizioso e potente frutto per i suoi molteplici benefici.
E' originario della Thailandia.
Utilizzato già da molte generazioni
Thailandia: proprietà astringenti
India: dissenteria, diarrea, malattie,
gastriche, gotta,febbre, ecc...
Joe Morton il fondatore di Xango
scopre il frutto nel 1995
Xango impiega 7 anni per creare le infrastrutture e ha una collaborazione in esclusiva con l'azienda Wild Flavors
• ISO 9001:2000ISO 9001:2000 Quality Standards• AIBAIB (American Baking Institute)
• NFPANFPA (National Food Procesors Association)
• CFPACFPA (Canadian Food Inspection Agency)
• C-TPAT CertificationC-TPAT Certification
Sono stati catalogati in natura 200 tipi di Xantoni.Principalmente si trovano nelle cortecce degli alberi
e nella buccia della Frutta
Il Mangostano ne possiede ben 43 tipi
Tabella ORAC.
Oxygen Radical Absorbance Capacity: Capacita' di assorbimento dei radicali liberi
Mangostano
TABELLA: Jean Mayer, Centro di ricerca nutrizione umana e invecchiamento dell’USDA(Dipartimento dell’Agricoltura degli Stati Uniti) presso la Tufts University di Boston,Massachusetts.
Il super Antiossidante
Molecola biologicamente attiva appartenente
al gruppo dei fenoli.
Possiede un anello coniugato di carbonio con sei legami doppi che la rendono altamente stabile.
Gli xantoni hanno più elettroni, quindi riducono l’effetto nocivo
dei radicali liberi
XANTONI RADICALELIBERO
Alcune situazioni associate ai danni ossidativi:
InvecchiamentoPeriossidazione da acidi grassi della membrana cellulare
AteriosclerosiPeriossidazione dei lipidi in particelle di LDL (colesterolo cattivo)
Tumore / Cancro Danno del DNA con mutazioni dello stesso
Cataratta
Modifica irreversibile delle proteine interoculari
Malattie infiammatorie cronicheAttivazione di geni relazionati con la risposta infiammatoria
L’ossidazione inizia a livello cellulare ed è il processo base di moltissime malattie
organoorgano
sistema
cellulacellula
tessutotessuto
Chi colpisce l’ossidazione ?
EQUILIBRIO
XANTONAS
MANGOSTÁN+
Malattie Relazionate con leInfiammazioni Croniche:
“L’ Infiammazione sta emergendo come l’alpha e l’ omega delle malattie del
cuore. - Phd Peter Libby
• Malattie Cardiovascolari • Diabete• Alzahimer• Parkinson• Cancro• Artriti• etc...
www.ammim.org
Xanthones 1813
Xantoni + antiossidanti 86
Xantoni + infiammazioni 18
Xantoni+ sistema immunitario 117
Xanthones + cancro 261
XANTHONES
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1: Free Radic Res. 1995 Aug;23(2):175-84.
Mangostin inhibits the oxidative modification of human low density lipoprotein.Williams P, Ongsakul M, Proudfoot J, Croft K, Beilin L.University of Western Australia, Department of Medicine, Royal Perth Hospital, Australia.The oxidation of low density lipoprotein (LDL) may play an important role in atherosclerosis. We investigated the possible antioxidant effects of mangostin, isolated from Garcinia mangostana, on metal ion dependent (Cu2+) and independent (aqueous peroxyl radicals) oxidation of human LDL. Mangostin prolonged the lagtime to both metal ion dependent and independent oxidation of LDL in a dose dependent manner over 5 to 50 microM as monitored by the formation of conjugated dienes at 234 nm (P < 0.001). There was no significant effect of mangostin on the rate at which conjugated dienes were formed in the uninhibited phase of oxidation. Levels of thiobarbituric reactive substances (TBARS) generated in LDL were measured 4 and 24 hours after oxidation with 5 microM Cu2+ in the presence or absence of 50 microM or 100 microM mangostin. We observed an inhibition of TBARS formation with 100 microM mangostin at 4 hours (P = 0.027) but not at 24 hours (P = 0.163). Similar results were observed in the presence of 50 microM mangostin. Mangostin, at 100 microM, retarded the relative electrophoretic mobility of LDL at both 4 and 24 hours after Cu2+ induced oxidation. Mangostin (100 microM) significantly inhibited the consumption of alpha-tocopherol in the LDL during Cu2+ initiated oxidation over a 75 minute period (P < 0.001). From these results, we conclude that mangostin is acting as a free radical scavenger to protect the LDL from oxidative damage in this in vitro system.
Da questi studi, concludiamo che il Mangostano agisce come INIBITORE di Radicali Liberi proteggendo dal danno ossidativo del LDL.
Da questi studi, concludiamo che il Mangostano agisce come INIBITORE di Radicali Liberi proteggendo dal danno ossidativo del LDL.
SISTEMA CARDIO VASCULAR
Mahabusarakam W, Proudfoot J, Taylor W, Croft KInhibition of lipoprotein oxidation by prenylated xanthones derived from mangostin. Free Radic Res. 2000 Nov;33(5):643-59PMID: 11200095 {PubMed- indexed for MedLine}Chemistry Department, Prince of Songkla University, Hat Yai, Thailand
Jiang DJ, Hu GY, Jiang JL, Hiang HL, Deng HW, Li YJRelationship between protective effect of xanthone on endothelial cells and endogeous nitric oxide synthase inhibitors.Bioorg Med Chem. 2003 Nov 17; 11 (23):5171-7PMID: 14604680 {PubMed- indexed for MedLine}
STUDI DI ATTIVITA’ ANTIOSSIDANTE
SISTEMA RESPIRATORIO
Chairungsrilerd N, Furukawa K, Otha T, Nozoe S, Ohizumi Y.Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia MangostanaPlanta Med, 1996 Oct; 62(5): 471-2PMID: 8923814 {PubMed- indexed for MedLine}
Chairungsrilerd N, Furukawa K, Otha T, Nozoe S, Ohizumi Y.Pharmacological properties of alfa mangostin, a novel histamine H1 receptor antagosnist.Eur J Pharmacol, 1996 Oct; 314 (3): 351-6PMID: 8957258 {PubMed- indexed for MedLine}Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
ALCUNI STUDI SULL’AZIONE ANTISTAMINICA
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1: Planta Med. 2002 Nov;68(11):975-9. Related Articles, Links Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines.Ho CK, Huang YL, Chen CC.Department of Medical Research & Education, Veterans General Hospital, Taipei, ROC.Treatment of hepatocellular carcinomas (HCCs) with chemotherapy has generally been disappointing and it is most desirable to have more effective new drugs. We extracted and purified 6 xanthone compounds from the rinds (peel) of the fruits of Garcinia mangostana L., using partitioned chromatography and then tested the cytotoxic effects of these compounds on a panel of 14 different human cancer cell lines including 6 hepatoma cell lines, based on the MTT method. Several commonly used chemotherapeutic agents were included in the assay to determine the relative potency of the potential new drugs. Our results have shown that one of the xanthone derivatives which could be identified as garcinone E has potent cytotoxic effect on all HCC cell lines as well as on the other gastric and lung cancer cell lines included in the screen. We suggest that garcinone E may be potentially useful for the treatment of certain types of cancer.Publication Types: * Research Support, Non-U.S. Gov't
PMID: 12451486 [PubMed - indexed for MEDLINE]
Garcinone E è un derivato di xantone ed ha un potente effetto citotossico sul carcinoma hepatocelular.
noi supponiamo che il Garcinone E, possa essere un potenziale utiletrattamento per alcuni tipi di cancro.
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1: Fitoterapia. 2004 Jun;75(3-4):375-7. Related Articles, Links Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line.Moongkarndi P, Kosem N, Luanratana O, Jongsomboonkusol S, Pongpan N.Department of Microbiology, Faculty of Pharmacy, Mahidol University, Rajdhevee, Sri Ayudthaya Rd, Bangkok 10400, Thailand. [email protected] extracts of selected nine Thai medicinal plants were tested for antiproliferative activity against SKBR3 human breast adenocarcinoma cell line using MTT assay. Garcinia mangostana showed the most potent activity. However, all plant extracts showed activity in potential range for further investigation on cancer cells. Copyright 2004 Elsevier B.V.Publication Types: * Research Support, Non-U.S. Gov't
PMID: 15158999 [PubMed - indexed for MEDLINE]
Attività antiproliferativa del cancro al seno nell’estratto della pianta medicinale
Tailandese
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1: J Nat Prod. 2003 Aug;66(8):1124-7. Related Articles, Links Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y.Gifu International Institute of Biotechnology, 1-1 Naka-Fudogaoka, Kakamigahara, Gifu 504-0838, Japan. [email protected] examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis.PMID: 12932141 [PubMed - indexed for MEDLINE]
Gli Xantoni del mangostano inducono rallentamenti (della leucemia)
J Ethnopharmacol. 2005 Oct 3;101(1-3):330-3.
Antimicrobial effects of Thai medicinal plants against acne-inducing
bacteria.
Chomnawang MT, Surassmo S, Nukoolkarn VS, Gritsanapan W.
Department of Microbiology, Faculty of Pharmacy, Mahidol University, 447 Sri Ayudthaya
Road, Rachathevi, Bangkok 10400, Thailand. [email protected]
Propionibacterium acnes and Staphylococcus epidermidis have been recognized as pus-
forming bacteria triggering an inflammation in acne. The present study was conducted to
evaluate antimicrobial activities of Thai medicinal plants against these etiologic agents of
acne vulgaris. Crude extracts were tested for antimicrobial activities by disc diffusion and
broth dilution methods. The results from the disc diffusion method showed that 13 medicinal
plants could inhibit the growth of Propionibacterium acnes. Among those, Senna alata,
Eupatorium odoratum, Garcinia mangostana, and Barleria lupulina had strong inhibitory
effects. Based on a broth dilution method, the Garcinia mangostana extract had the greatest
antimicrobial effect. The MIC values were the same (0.039 mg/ml) for both bacterial species
and the MBC values were 0.039 and 0.156 mg/ml against Propionibacterium acnes and
Staphylococcus epidermidis, respectively. In bioautography assay, the Garcinia mangostana
extract produced strong inhibition zones against Propionibacterium acnes. Antimicrobial
activity from fractions of column chromatography revealed one of the active compounds in
Garcinia mangostana could be mangostin, a xanthone derivative. Taken together, our data
indicated that Garcinia mangostana had a strong inhibitory effect on
Propionibacterium acnes and Staphylococcus epidermidis. Therefore, this plant
would be an interesting topic for further study and possibly for an alternative treatment for
acne.
Publication Types: Research Support, Non-U.S. Gov’t
PMID: 16009519 [PubMed - indexed for MEDLINE]
PELLEPELLE•ECZEMAECZEMA
• PSORIASIPSORIASI
• ACNEACNE
• DERMATITE DERMATITE
ATOPICAATOPICA
La garcinia mangostana ha un potente effetto inibitorio nel Propionibacterium acnes
così come nel Staphilococcus epidermis ( acne)
La garcinia mangostana ha un potente effetto inibitorio nel Propionibacterium acnes
così come nel Staphilococcus epidermis ( acne)
:
Associazione Americana contro il Cancro
CONSULTA LE SEGUENTI PAGINE WEB
www.xango.com
Siti di medicina
www.pubmed.gov
(xanthones ó mangosteen)
www.mangosteenmd.com
www.ammim.org
Cosa è che rende
Xango così Unico ?
INGREDIENTES ACTIVOS DEL MANGOSTAN
GLI XANTONI Estilbenos (funghi)
Quinonas (antibiotico, tetra)
Tannini presenti nel vino rosso
Polisaccaridi sono presenti nell'aloe
Catequinas sono presenti nel te verde
Proantocianidinas eEsteroles (antiossidanti)
Potassio (25 mg/oz)
CalcioFerroFosforoVitamina B1, B2, B6 Vitamina C
I Fitonutrienti del Mangostano
Xango può aiutarci come: Anti InfiammatorioAnti AllergicoAnti ArtriticoAnti pirettico Anti viraleAntibioticoAnsioliticoStimolante ImmunologicoCataratta e Glaucoma
Pelle e AllergieSistema RespiratorioAsma BronchialeVertiginiEccelente nella sclerosi Multipla e FibromialgieArtriti, osteoartrite reumatoide e degenerativaSistema DigestivoColiteDiarreaStitichezzaDepressioneInsonnia
Potente antiossidante Protegge il sistema CardiovascolareMigliora il colesteroloMigliora i TrigliceridiAiuta nell’ipertensioneAiuta a controllare il Diabete tipo I e tipo IIAiuta il Sistema Nervoso Centrale aiutando i pazienti con Alzaimer, ParkinsonPreviene l’Osteoporosi
UN’OTTIMA SOLUZIONE
Senza dubbio SARA’ l’antiossidante più conosciuto di tutti i tempi!
Dr. Frederic Templeman
DOSI
AGLI ADULTI SONO CONSIGLIATI
30 ml GIORNALIERI
AI BAMBINI SONO CONSIGLIATIDA 1 A 7 ANNI: 15 ml.
GIORNALIERIOLTRE I 7 ANNI: DOSI DA
ADULTO
PRECAUZIONI:USO DI ANTICOAGULANTI
NON E' UN PRODOTTO CURATIVO
XANGO
HA UN VALORE
DI 28 EURO
CONSUMO
RISPETTANDO LA DOSE GIORNALIERA (30ml.) SI OTTENGONO 25 PORZIONI
VALORE DELLA PORZIONE
CIRCA 1 € AL GIORNO, IL VALORE DI UN CAFFE' !
“SPIACEVOLMENTEPOCA GENTE INVESTE SULLA PROPRIA
SALUTE, LA MAGGIOR PARTE SPENDE IN MALATTIE”
Dott.ssa Angelita Martin Dott.ssa Angelita Martin FerreiraFerreira
“BERE L'ESTRATTO DI MANGOSTANO E' PARAGONABILE A UNA ASSICURAZIONE
SULLA VITA”